Libertador Miguel Hidalgo International Airport GDL is located south of the city along the Guadalajara-Chapala Highway. Along with Mexico's main domestic carriers - AeroMexico, Volaris, Interjet and VivaAerobus - major airlines, including Alaska Airlines,American Airlines, Copa Airlines, Delta, United has the largest number of flights to the US and US Airways serve Guadalajara. A taxi from the airport from anywhere will cost $220 but many hotels offer airport pickups that can be cheaper. There is also a bus that stops at the bottom of Terminal 1 which goes to the Central Camionera Vieja close to the historic centre and costs $6. A taxi down to the Lake Chapala area around Ajijic or Chapala will cost about $380. At the airport always buy the taxi chit from the booth before exiting the terminal. Present the chit to the licenced driver.
The new main bus station is in the suburb of Tonalá, which serves all routes further than 100km or so, generally those which leave the state of Jalisco. The old bus station just south of the centro is served by bus lines motoring to nearby pueblos like Tequila and Chapala. Be warned that bus rides can sometimes be a bit jumpy and jittery because of the state of the roads, but the buses themselves are very comfortable. A taxi from the new bus station to the Centro Historico should cost around $60, or you can get a city bus which will cost $6 unless you get a TUR bus which costs $10, just ask for 'centro'.
